AKT (Protein Kinase B or PKB), is a serine/threonine-specific protein kinase with known key involvement in glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
Recent advances in AKT signaling have focused on understanding cellular processes and identifying cellular substrates that are physiologically relevant in vivo. These efforts have uncovered important roles for AKT regulation in cancer research, neuroscience and disease prevention.
Isoforms of AKT are found to be distinct with regard to tissue expression, pathway activation and inhibitor sensitivity.
tebu-bio has selected a panel of monoclonal antibodies to AKT isoforms suitable for probing lysates and pharmacodynamic studies.
Activation of AKT results in phosphorylation of a wide range of proteins downstream of the AKT pathway. The phosphorylated substrates, present in various subcellular locations play an important role in directing different phenotypic outcomes. Faulty or aberrant activation of AKT underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes, HIV and cancer. When constitutively active, AKT is utilized frequently by cancer cells to circumvent therapeutic intervention, promoting cellular survival and resistance to chemo and radiation therapy. Rockland’s Anti-AKT antibodies help monitor levels of AKT and its phosphorylation at position S473, T308, as well as AKT isoforms AKT2 and AKT3.
A selection of 100% guaranteed research antibodies related to the AKT pathway
- Anti AKT (Pan): a rabbit polyclonal
- Anti p-AKT pT308: a mouse monoclonal
- Anti p-AKT pS473: a mouse monoclonal
- Anti p-ATM pS1981: a mouse mononclonal, recognizes the product of the ATM gene
To explore even further, take a look at our AKT pathway antibodies offer….
- AKT antibodies (including AKT1, AKT2 and AKT3)
- Anti phospho m-TOR
- Anti PtdIns (3,4,5) P3
- Anti PtdIns (3,4) P2
Looking for a specific intracellular pathway?
We strive to provide you regularly with new and updated pathways to support you in your research. If you are looking for a specific pathway, don’t hesitate to contact us.