In this study, the authors investigated the modulatory effects of LIM-only protein FHL2/DRA/SLIM3 in phenotypic changes of Smooth Muscles Cells (SMC) in SMC-rich lesion formation.
They have found that FHL2 regulates SMC’s functions during vascular proliferative diseases by modulating Cyclin D1 expression via ERK 1/2 signaling pathway.
Congratulations to the authors, who turned to tebu-bio’s range of products when selecting their growth factors to culture aortic SMC for in vitro scratch-wound and migration assays.
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Source: Karakula K. et al. “The LIM-Only Protein FHL2 Reduces Vascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells” (2014) 9(4): e94931. doi:10.1371/journal.pone.0094931
Related research products:
- A complete offer of active Cytokines and Growth factors and Chemokines PeproTEch including recombinant Mouse PDGF-BB.
- A characterized source of primary Smooth Muscle Cells (SMC) from Human, Mouse, Rat, Bovine origin.
- FHL2 research reagents (from primary antibodies to siRNA, expression vectors and, Gene Reporter Assays, miRNA…).
- Transwell-free in vitro ORIS migration assays.
Oris Cell Migration Assay Video